The mounting evidence of severe health effects in humans following COVID-19 vaccination warrants additional investigation. To add to the pile of evidence, a new study has found that the nanoparticles in the mRNA vaccine change the immune system.
A recent preprint study sheds light on why adverse events were detected after a COVID-19 messenger RNA (mRNA) immunization.
The study (read below), coordinated by Thomas Jefferson University researchers, discovered that lipid nanoparticles (LNPs) used to carry mRNA in COVID-19 vaccinations might “inhibit” and “alter” immune responses in mice.
LNPs are lipid shells that surround mRNA to evade degradation and detection by our immune system.
LNPs are not mRNA; they are merely a covering for the mRNA cargo.
The mRNA COVID-19 vaccines from Pfizer and Moderna utilise LNPs to introduce mRNA spike protein sequences into human cells. Human cells will produce spike proteins after receiving the mRNA sequences, which will then cause an immunological response.
Initially, it was planned for the LNPs to covertly introduce mRNA sequences that would cause the cells to create spike proteins and therefore develop immunity to the COVID-19 virus.
However, numerous researches in mice have now discovered that the LNPs, despite being advertised as harmless and non-toxic, are instead very inflammatory.
These nanoparticles are extremely long-lasting and can stay in the body for 20 to 30 days. They are likely to stay in the body and continue to stimulate the immune system, which will eventually wear out and become non-responsive.
Similar conclusions were also reached by the Thomas Jefferson research. By injecting animals with the identical LNPs found in Pfizer’s vaccines—some mice even received two doses—researchers examined how LNPs influence the immune system.
Immune responses and inflammation in mice are not absolute indicators of what will occur in people. Nevertheless, mice have long been used to assess the efficacy and safety of medications intended for human use; symptoms of immunological dysfunction are a hint of potential health hazards in people.
The researchers discovered that mice given two doses had a weaker immunological response to their second injection than mice given only one dosage.
“The mRNA-LNP (nanoparticle) vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections,” the authors wrote.
Pre-Exposure to mRNA Nanoparticles Reduce Innate Cell Numbers
Mice that received two doses of LNP injections had less innate immune cells, which are the primary immune cells.
By injecting mice with various LNP variants, the authors hoped to learn how the mRNA-sealing LNPs affected the mice.
The mice were divided into three groups, each of which received two injections with various substances.
Most mice received an injection of LNP as the initial injection. The second half received empty LNPs with no mRNA while the first half received LNPs having mRNA sequences.
An injection of salty water was given to the leftover mice. Since injections of salted water are not meant to cause any alterations to the body, these mice serve as the baseline to compare.
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Approximately two weeks later, all 3 groups received the same LNP injection carrying influenza protein mRNA sequences (HA). The second injection stimulated their cells to produce HA proteins, resulting in an immunological response. It was hoped that the immunological response would render the mice immune to the influenza virus.
After the second injection, the researchers discovered that all mice had established immunological defenses against the influenza virus.
The researchers found that mice who received two doses of LNPs lost less weight and were more resistant to an influenza illness. Oddly enough, the same mice also responded to the flu vaccine with a less potent immunological response and less activation of immune cells.
According to the authors’ assumption, their “resistance” likely results from an alternate pathway that LNPs have activated rather than from a boosted immune system. This “resistance” may only be applicable to influenza and is not yet known if it will apply to other illnesses.
This is due to the study’s discovery that mice who appeared to be more “resistant” to the flu were in fact more prone to fungus infections.
When the mice were given two doses of the Candida albicans infection, the mice lost more weight and had less success fighting the illness, indicating a change in the innate immune response.
Additional research revealed that these mice had less neutrophils, the most prevalent type of first-responder immune cell.
Neutrophils are responsible for patrolling the body and indiscriminately attacking anything foreign they come across, thus having less of them increases the risk of infection.
The scientists hypothesized that decreased neutrophil counts may have contributed to the fungal outbreak since an unchecked fungal infection, particularly C. albicans, is frequently a symptom of compromised innate or first responder immune response.
LNPs trigger inflammation, and specific inflammatory pathways limit blood cell formation. The scientists hypothesized that the two dosages of LNPs given to these mice induced increased inflammation, resulting in a decrease in blood cell formation and low neutrophil numbers.
Though this is speculative, and it is unknown if the effects in mice would translate to humans, there have been instances of vaccinated people developing severe aplastic anemia, a condition in which the body can no longer produce enough blood cells, especially red blood cells.
There have also been instances of COVID-19 vaccine recipients acquiring rare fungal infections or aggravating pre-existing fungal disorders.
Though major fungal disease does not always indicate a weakened immune system, serious fungal infections “are most common among people with weak immune systems,” according to the Centers for Disease Control and Prevention (CDC).
Antigen Numbers Reduced in Mice with High Nanoparticle Exposure
There are two types of immune cells: first responders (innate immune cells) and second responders (adaptive immune cells).
When they come upon something strange, the first responders launch an immediate assault. However, their attacks are generic and frequently fail to completely remove illnesses.
As a result, adaptive immune cells, also known as T and B cells, act as our second line of defense.
They become active about a week into the infection and clear infections by launching powerful and targeted attacks.
T and B cells must be supplied with pathogen information in order to activate adaptive immune cells. It could be a portion of the spike protein in the case of Sars-Cov-2.
APCs (antigen-presenting cells), a kind of first-responding cell, deliver virus, bacterium, or infectious particle fragments to adaptive T or B cells. This activates T or B cells, resulting in an adaptive immunological response.
A dendritic cell (APC) activates a T cell by presenting it with an antigen, a harmful or foreign substance.
However, the researchers discovered that mice that received two doses of mRNA LNPs displayed less antigen than mice that received just one dose.
This suggests that less adaptive immune cell activation against influenza proteins was produced.
mRNA Nanoparticles Reduce T and B cell Responses
The T and B cell responses to the flu mRNA vaccination were shown to be less robust in mice that had received two injections of LNP compared to those who had only received one.
T and B cells are essential for our immune system’s capacity to eradicate infections since they are the last line of defense.
However, reduced T and B cell activation was observed in mice who received two doses of LNP.
The quantities of antibodies (B cells produce antibodies) against the influenza protein were likewise lower in the double-dosed groups.
The decreased adaptive immune response was systemic, impacting all organs and areas. According to the scientists, this reduction was considerably greater at the injection site, particularly if the mice were administered injections at the same location for both shots.
The group that received only one injection of LNP, on the other hand, exhibited stronger T and B cell responses, as well as more antibodies generated.
The authors discovered that LNP exposure reduced T progenitor cells. Because T progenitor cells mature into activated T cells, fewer progenitors imply fewer T cells and a lower response.
The scientists discovered that removing T progenitor cells before immunization and then reintroducing them after vaccination did not diminish the number of activated T cells. This shows that the LNP lowers the amount of T progenitor cells and, as a result, the T cell response.
“Pre-exposure to mRNA-LNP inhibits T cell responses,” the authors wrote.
The authors speculated that the lowered immunity ought not to be permanent.
They discovered that if an 8-week gap was introduced between the first and second dosages, B cell responses mostly rebounded.
Nonetheless, the authors did not confirm the time required for complete recovery, nor did they confirm whether the mice’s B cell response ever restored.
However, treating mice with adjuvants such aluminum salts or AddaVax reversed the suppressive effects of LNP injections on mice immune cells.
“Inhibition of the adaptive immune responses by pre-exposure to mRNA-LNPs is long-lasting but it is likely to wane with time.”
Immunity Changes from LNPs Can Be Inherited
As previously stated, mice given two doses of LNPs were more resistant to an influenza infection than mice given only one dosage of LNPs.
This was confirmed by the mice’s greater weight maintenance throughout infection, albeit it is unclear if the resistance was due to an immunological response or another mechanism initiated by the LNPs.
Surprisingly, this enhanced defensiveness may be handed down to their kids. The inheritance of influenza resistance is stronger when both parents are vaccinated, and less so when only one parent is inoculated, especially if only the male father is immunized.
The study did not address whether the kids also inherit immunological deficiency, such as a loss in immunity against C. albicans, which was observed in mice given two LNPs dosages.
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Implication of the Study and Pressing Questions
The results of the mice study indicate that T and B cell functions temporarily decline in mice, which begs the issue of whether this also happens in people.
Clearing infections and preventing chronic illnesses like cancer depend on the adaptive immune response. According to the study, mice are more susceptible to infections and cancer for a few weeks following two vaccines with the mRNA LNPs.
Although there has not been a study conclusively proving a correlation, similar findings have also been made regarding human observations.
However, an increased prevalence of sickness reported to the Vaccine Adverse Event Reporting System (VAERS) following COVID-19 vaccination implies that patients have less immunity after vaccination.
There have been numerous cases of cancers developing as a result of COVID-19 vaccines.
In the VAERS database, 284 incidences of breast cancer were recorded following COVID-19 immunization, although only 350 cases had been reported in the VAERS database’s whole history.
There were 269 cases of leukemia reported following COVID-19 vaccination, compared to 432 cases throughout VAERS’s whole history.
Furthermore, there have been instances of new onset and recurring shingles following COVID-19 vaccinations. VAERS data shows that 7,559 incidences of shingles have been reported following COVID-19 vaccination.
Throughout the lifetime of VAERS, 28,180 cases of shingles have been documented following any immunization, implying that COVID-19 vaccination accounted for around a quarter of all shingles cases.
According to the CDC, a new diagnosis or recurrence of shingles occurs largely in patients with compromised immune systems and is a symptom of decreased immunity.
Though the mice study shows significant human health consequences, it is unknown whether all of the symptoms and effects reported in mice would occur in humans.
Nonetheless, mounting evidence of severe health effects in humans following COVID-19 vaccination warrants additional investigation. It is also necessary to investigate the overlaps between the health consequences for mice and people.
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“Considering the broad exposure of a large proportion of human populations to vaccines based on this novel (mRNA) technology, more studies are warranted to fully understand its overall immunological and physiological effects. Determining this platform’s short and long-term impact on human health would help optimize it to decrease its potentially harmful effects,” the authors concluded.
Article cross-posted from Great Game India.
Five Things New “Preppers” Forget When Getting Ready for Bad Times Ahead
The preparedness community is growing faster than it has in decades. Even during peak times such as Y2K, the economic downturn of 2008, and Covid, the vast majority of Americans made sure they had plenty of toilet paper but didn’t really stockpile anything else.
Things have changed. There’s a growing anxiety in this presidential election year that has prompted more Americans to get prepared for crazy events in the future. Some of it is being driven by fearmongers, but there are valid concerns with the economy, food supply, pharmaceuticals, the energy grid, and mass rioting that have pushed average Americans into “prepper” mode.
There are degrees of preparedness. One does not have to be a full-blown “doomsday prepper” living off-grid in a secure Montana bunker in order to be ahead of the curve. In many ways, preparedness isn’t about being able to perfectly handle every conceivable situation. It’s about being less dependent on government for as long as possible. Those who have proper “preps” will not be waiting for FEMA to distribute emergency supplies to the desperate masses.
Below are five things people new to preparedness (and sometimes even those with experience) often forget as they get ready. All five are common sense notions that do not rely on doomsday in order to be useful. It may be nice to own a tank during the apocalypse but there’s not much you can do with it until things get really crazy. The recommendations below can have places in the lives of average Americans whether doomsday comes or not.
Note: The information provided by this publication or any related communications is for informational purposes only and should not be considered as financial advice. We do not provide personalized investment, financial, or legal advice.
Secured Wealth
Whether in the bank or held in a retirement account, most Americans feel that their life’s savings is relatively secure. At least they did until the last couple of years when de-banking, geopolitical turmoil, and the threat of Central Bank Digital Currencies reared their ugly heads.
It behooves Americans to diversify their holdings. If there’s a triggering event or series of events that cripple the financial systems or devalue the U.S. Dollar, wealth can evaporate quickly. To hedge against potential turmoil, many Americans are looking in two directions: Crypto and physical precious metals.
There are huge advantages to cryptocurrencies, but there are also inherent risks because “virtual” money can become challenging to spend. Add in the push by central banks and governments to regulate or even replace cryptocurrencies with their own versions they control and the risks amplify. There’s nothing wrong with cryptocurrencies today but things can change rapidly.
As for physical precious metals, many Americans pay cash to keep plenty on hand in their safe. Rolling over or transferring retirement accounts into self-directed IRAs is also a popular option, but there are caveats. It can often take weeks or even months to get the gold and silver shipped if the owner chooses to close their account. This is why Genesis Gold Group stands out. Their relationship with the depositories allows for rapid closure and shipping, often in less than 10 days from the time the account holder makes their move. This can come in handy if things appear to be heading south.
Lots of Potable Water
One of the biggest shocks that hit new preppers is understanding how much potable water they need in order to survive. Experts claim one gallon of water per person per day is necessary. Even the most conservative estimates put it at over half-a-gallon. That means that for a family of four, they’ll need around 120 gallons of water to survive for a month if the taps turn off and the stores empty out.
Being near a fresh water source, whether it’s a river, lake, or well, is a best practice among experienced preppers. It’s necessary to have a water filter as well, even if the taps are still working. Many refuse to drink tap water even when there is no emergency. Berkey was our previous favorite but they’re under attack from regulators so the Alexapure systems are solid replacements.
For those in the city or away from fresh water sources, storage is the best option. This can be challenging because proper water storage containers take up a lot of room and are difficult to move if the need arises. For “bug in” situations, having a larger container that stores hundreds or even thousands of gallons is better than stacking 1-5 gallon containers. Unfortunately, they won’t be easily transportable and they can cost a lot to install.
Water is critical. If chaos erupts and water infrastructure is compromised, having a large backup supply can be lifesaving.
Pharmaceuticals and Medical Supplies
There are multiple threats specific to the medical supply chain. With Chinese and Indian imports accounting for over 90% of pharmaceutical ingredients in the United States, deteriorating relations could make it impossible to get the medicines and antibiotics many of us need.
Stocking up many prescription medications can be hard. Doctors generally do not like to prescribe large batches of drugs even if they are shelf-stable for extended periods of time. It is a best practice to ask your doctor if they can prescribe a larger amount. Today, some are sympathetic to concerns about pharmacies running out or becoming inaccessible. Tell them your concerns. It’s worth a shot. The worst they can do is say no.
If your doctor is unwilling to help you stock up on medicines, then Jase Medical is a good alternative. Through telehealth, they can prescribe daily meds or antibiotics that are shipped to your door. As proponents of medical freedom, they empathize with those who want to have enough medical supplies on hand in case things go wrong.
Energy Sources
The vast majority of Americans are locked into the grid. This has proven to be a massive liability when the grid goes down. Unfortunately, there are no inexpensive remedies.
Those living off-grid had to either spend a lot of money or effort (or both) to get their alternative energy sources like solar set up. For those who do not want to go so far, it’s still a best practice to have backup power sources. Diesel generators and portable solar panels are the two most popular, and while they’re not inexpensive they are not out of reach of most Americans who are concerned about being without power for extended periods of time.
Natural gas is another necessity for many, but that’s far more challenging to replace. Having alternatives for heating and cooking that can be powered if gas and electric grids go down is important. Have a backup for items that require power such as manual can openers. If you’re stuck eating canned foods for a while and all you have is an electric opener, you’ll have problems.
Don’t Forget the Protein
When most think about “prepping,” they think about their food supply. More Americans are turning to gardening and homesteading as ways to produce their own food. Others are working with local farmers and ranchers to purchase directly from the sources. This is a good idea whether doomsday comes or not, but it’s particularly important if the food supply chain is broken.
Most grocery stores have about one to two weeks worth of food, as do most American households. Grocers rely heavily on truckers to receive their ongoing shipments. In a crisis, the current process can fail. It behooves Americans for multiple reasons to localize their food purchases as much as possible.
Long-term storage is another popular option. Canned foods, MREs, and freeze dried meals are selling out quickly even as prices rise. But one component that is conspicuously absent in shelf-stable food is high-quality protein. Most survival food companies offer low quality “protein buckets” or cans of meat, but they are often barely edible.
Prepper All-Naturals offers premium cuts of steak that have been cooked sous vide and freeze dried to give them a 25-year shelf life. They offer Ribeye, NY Strip, and Tenderloin among others.
Having buckets of beans and rice is a good start, but keeping a solid supply of high-quality protein isn’t just healthier. It can help a family maintain normalcy through crises.
Prepare Without Fear
With all the challenges we face as Americans today, it can be emotionally draining. Citizens are scared and there’s nothing irrational about their concerns. Being prepared and making lifestyle changes to secure necessities can go a long way toward overcoming the fears that plague us. We should hope and pray for the best but prepare for the worst. And if the worst does come, then knowing we did what we could to be ready for it will help us face those challenges with confidence.
